Motegrity (prucalopride) is a serotonin-4 (5-HT4) receptor agonist used in the treatment of gastrointestinal disorders. Motegrity is a prescription medicine used to treat chronic idiopathic constipation Idiopathic means without a known cause.
What is prucalopride?
Prucalopride is used to treat chronic idiopathic constipation (constipation without a known cause).
Prucalopride may also be used for purposes not listed in this medication guide.
You should not use prucalopride if you have a blockage in your intestines, Crohn's disease, ulcerative colitis, or intestinal perforation.
Before taking this medicine
You should not use prucalopride if you are allergic to it, or if you have:
- a blockage in your intestines;
- severe constipation;
- inflammatory bowel disease (Crohn's disease, ulcerative colitis);
- toxic megacolon; or
- perforation (a hole or tear) of your intestines.
Tell your doctor if you have ever had:
- kidney disease;
- a mood disorder; or
- suicidal thoughts.
Tell your doctor if you are pregnant or breast-feeding.
Prucalopride is not approved for use by anyone younger than 18 years old.
How should I take prucalopride?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
You may take prucalopride with or without food.
Store prucalopride in the original container at room temperature, away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What should I avoid while taking prucalopride?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Prucalopride side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using prucalopride and call your doctor at once if you have:
- unusual changes in mood or behavior;
- ongoing or worsening depression;
- thoughts about suicide or hurting yourself; or
- if you feel sad or hopeless.
Common side effects may include:
- nausea, vomiting, diarrhea;
- stomach pain, bloating, gas;
- dizziness; or
- feeling tired.
What other drugs will affect prucalopride?
Other drugs may affect prucalopride, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.